Human Neonatal Cardiovascular Progenitors: Unlocking the Secret to Regenerative Ability

Human Neonatal Cardiovascular Progenitors: Unlocking the Secret to Regenerative Ability

Although clinical benefit can be achieved after cardiac transplantation of adult c-kit+ or cardiosphere-derived cells for myocardial repair, these stem cells lack the regenerative capacity unique to neonatal cardiovascular stem cells. Unraveling the molecular basis for this age-related discrepancy in function could potentially transform cardiovascular stem cell transplantation. In this report, ...

On the Appli ability of Regenerative

Cardiovascular regenerative biology.

et al. (pp. 48–59), Naito et al. (pp. 60–72), Majesky et al. (pp. 73–81), and Peter et al. (pp. 82–93) provide an excellent overview of the importance of the microenvironmental niche for cell fate. These manuscripts also contribute to our understanding of the importance of the innate immune response to cell fate after implantation. The clinical applications related to the formation of blood ves...

A strong regenerative ability of cardiac stem cells derived from neonatal hearts.

BACKGROUND Human cardiac stem cells (CSCs) promote myocardial regeneration in adult ischemic myocardium. The regenerative capacity of CSCs in very young patients with nonischemic congenital heart defects has not been explored. We hypothesized that isolated neonatal-derived CSCs may have a higher regenerative ability than adult-derived CSCs and might address the structural deficiencies of congen...

Human Pluripotent Stem Cells in Cardiovascular Research and Regenerative Medicine

Heart disease is one of the leading causes of mortality worldwide. Because adult cardiomyocytes (CMs) lack the ability to regenerate, malfunctions or significant loss of CMs due to disease or aging can lead to cardiac arrhythmias, heart failure, and subsequently death. Heart transplantation for patients with end stage heat failure is limited by the number of donor organs available. Cell-based t...